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severe or ongoing indigestion;Very common (10% or more): Depression (up to 19%), insomnia (included dreams/sleeping problems; up to 16.3%), anxiety (up to 13%)

GastrointestinalSitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Sitagliptin is present in JANUMET tablets in the form of sitagliptin phosphate monohydrate. Sitagliptin phosphate monohydrate is described chemically as 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate (1:1) monohydrate with an empirical formula of C16H15F6N5OH3PO4H2O and a molecular weight of 523.32. The structural formula is:Enbrel 25 mg prefilled syringe 0.51 mL of a 50 mg/mL solution of etanercept 1% sucrose

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Other non-stimulant ADHD medications include Kapvay (extended-release clonidine) and Intuniv (extended-release guanfacine). Kapvay and Intuniv are FDA-approved to treat ADHD in children and adolescents 6 to 17 years old. However, they have not been studied extensively in adults and are therefore not FDA-approved for adult ADHD treatment. However, a small placebo-controlled, double-blinded crossover study showed a possible benefit of using immediate-release guanfacine to treat ADHD in adults.

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