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The acellular pertussis vaccine antigens are produced from Bordetella pertussis cultures grown in Stainer-Scholte medium8 modified by the addition of casamino acids and dimethyl-beta- cyclodextrin. PT, FHA and PRN are isolated separately from the supernatant culture medium.

According to the National Comorbidity Survey Replication, a nationwide household survey of 18 to 44 year-olds, 4.4% of adults in the U.S. have ADHD. Surveys conducted by the National Institutes of Health report a prevalence of 3 to 5%, with comparable rates between men and women.

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Psychiatric symptoms generally began the first or second day of therapy and often resolved after 2 to 4 weeks. Patients with history of psychiatric disorders were at greater risk of serious psychiatric side effects. Psychiatric side effects classified as serious during controlled trials included severe depression, suicidal ideation, nonfatal suicide attempts, aggressive behavior, paranoid reactions, and manic reactions. One percent of patients discontinued or interrupted therapy due to at least 1 of these side effects.Bupropion (Wellbutrin) may increase the risk of seizures, especially at higher doses. It may also cause a significant increase in blood pressure. About one out of every three patients using bupropion experiences insomnia. Bupropion may cause dry mouth.